Article

Scaling perturbations: beyond genome-scale CRISPR screens

2026-01-17

Abstract excerpt

CRISPR screens have become essential tools for systematically probing gene function from basic biology to drug discovery, yet important frontiers remain beyond genome scale. Probing regulatory elements, interpreting genetic variants, and mapping genetic interactions all challenge the sensitivity and scalability of existing approaches. Here we introduce two synergistic technologies to address these limitations. POR...

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Literature Corpus work: 987e2953-bfaf-5469-8055-bffc8a3371d7
DOI: 10.64898/2026.01.16.699948

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