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Article

Precise Characterization of Genetic Interactions in Cancer via Molecular Network Refining Processes.

International journal of molecular sciences - 15 Oct 2021

Jung Jinmyung, Hwang Yongdeuk, Ahn Hongryul, Lee Sunjae, Yoo Sunyong

Abstract excerpt

Genetic interactions (GIs), such as the synthetic lethal interaction, are promising therapeutic targets in precision medicine. However, despite extensive efforts to characterize GIs by large-scale perturbation screening, considerable false positives have been reported in multiple studies. We propose a new computational approach for improved precision in GI identification by applying constraints that consider...

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Identifiers

PMID: 34681774
DOI: 10.3390/ijms222011114
PMCID: PMC8540220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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