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Article

Multi-functional genome-wide CRISPR system for high throughput genotype-phenotype mapping.

Nature communications - 19 Dec 2019

Lian Jiazhang, Schultz Carl, Cao Mingfeng, HamediRad Mohammad, Zhao Huimin

Abstract excerpt

Genome-scale engineering is an indispensable tool to understand genome functions due to our limited knowledge of cellular networks. Unfortunately, most existing methods for genome-wide genotype-phenotype mapping are limited to a single mode of genomic alteration, i.e. overexpression, repression, or deletion. Here we report a multi-functional genome-wide CRISPR (MAGIC) system to precisely control the expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31857575
DOI: 10.1038/s41467-019-13621-4
PMCID: PMC6923430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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