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Synthetic genetic array analysis for global mapping of genetic networks in yeast.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014

Kuzmin Elena, Sharifpoor Sara, Baryshnikova Anastasia, Costanzo Michael, Myers Chad L, Andrews Brenda J, Boone Charles

Abstract excerpt

Genetic interactions occur when mutant alleles of two or more genes collaborate to generate an unusual composite phenotype, one that would not be predicted based on the expected combined effects of the individual mutant alleles. Synthetic Genetic Array (SGA) methodology was developed to automate yeast genetic analysis and enable systematic genetic interaction studies. In its simplest form, SGA consists of a...

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PMID: 25213244
DOI: 10.1007/978-1-4939-1363-3_10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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