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Article

A mutational scar-based genome-wide map of DNA double-strand break repair.

Nature communications - 8 May 2026

Barazas Marco, van Schendel Robin, Tijsterman Marcel

Abstract excerpt

Genome alterations arise from inaccurate DNA repair and accumulate as distinct mutational signatures. Here, we systematically interrogate the contribution of every protein-coding gene to double-strand break (DSB) repair by generating high-resolution outcome profiles following gene knockouts. Using a CRISPR/Cas9-based, massively parallel bulk screening approach, we establish a comprehensive catalogue of MUtational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42103732
DOI: 10.1038/s41467-026-72744-7
PMCID: PMC13269935

Genes

POLQ
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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