Article
Genetic determinants of micronucleus formation in vivo.
Nature - 1 Mar 2024
Adams D J, Barlas B, McIntyre R E, Salguero I, van der Weyden L, Barros A, Vicente J R, Karimpour N, Haider A, Ranzani M, Turner G, Thompson N A, Harle V, Olvera-León R, Robles-Espinoza C D, Speak A O, Geisler N, Weninger W J, Geyer S H, Hewinson J, Karp N A, Fu B, Yang F, Kozik Z, Choudhary J, Yu L, van Ruiten M S, Rowland B D, Lelliott C J, Del Castillo Velasco-Herrera M, Verstraten R, Bruckner L, Henssen A G, Rooimans M A, de Lange J, Mohun T J, Arends M J, Kentistou K A, Coelho P A, Zhao Y, Zecchini H, Perry J R B, Jackson S P, Balmus G
Abstract excerpt
Genomic instability arising from defective responses to DNA damage1 or mitotic chromosomal imbalances2 can lead to the sequestration of DNA in aberrant extranuclear structures called micronuclei (MN). Although MN are a hallmark of ageing and diseases associated with genomic instability, the catalogue of genetic players that regulate the generation of MN remains to be determined. Here we analyse 997 mouse mutant...
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