Article

Mutational signature catalogue <i>(MUSIC)</i> of DNA double-strand break repair

2025-04-29

Abstract excerpt

Genome alterations arise from inaccurate DNA repair, accumulating into distinct mutational signatures. Here, we investigate the role of every genomically encoded gene in double-strand break (DSB) repair by generating high-resolution outcome profiles following gene knockouts. Using a CRISPR/Cas9-based, massive-parallel bulk library approach, we construct a comprehensive, user-explorable mutational signature catalog...

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Literature Corpus work: 0aa479c7-abf4-54fb-8c55-852674725536
DOI: 10.1101/2025.04.29.650617

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