Article

A topographical atlas of αSyn dosage and cell-type expression in the mouse brain and periphery

2023-10-07

Abstract excerpt

Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and presents pathologically with Lewy pathology and dopaminergic neuron loss. Lewy pathology contains aggregated αSynuclein (αSyn), a protein encoded by the SNCA gene which is also mutated or duplicated in a subset of familial PD cases. Due to its predominant presynaptic localization, immunostaining for the protein results in d...

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Literature Corpus work: 5af170a9-1269-5b7f-9ad9-24cf7a68809d
DOI: 10.1101/2023.10.05.559770

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