Article

Endogenous state of α-synuclein protein alters susceptibility to Lewy-like pathology

2020-01-01

Abstract excerpt

Background and aims: Two human mutations affecting the α-synuclein protein confer the most clinical severity in Parkinson's disease; endogenous αSyn over-expression due to gene multiplication and αSynG51D due to a missense mutation. The main hypotheses include 1) αSyn over-expression may affect cortical neuronal differentiation, 2) αSyn over-expression influences vulnerability to Lewy-like pathology in human corti...

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Literature Corpus work: d10992c1-ba6e-512b-90ce-1b9969b33630
DOI: 10.7488/era/853

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