Article

Neuronal <i>SNCA</i> transcription during Lewy body formation

2023-08-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Misfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body disease (LBD) based on considerable evidence including a gene-dosage effect observed in relation to point mutations and multiplication of SNCA in familial Parkinson’s disease. A contradictory concept proposes early loss of the physiological α-syn as the major driver of neurodegeneratio...

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Literature Corpus work: b9c24b4c-edb2-51c0-9893-95c3122f4237
DOI: 10.1101/2023.08.19.553427

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