Article

Single cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging and disease

2023-04-20

Abstract excerpt

<h4>Summary</h4> The brain is spatially organized and contains unique cell types, each performing diverse functions, and exhibiting differential susceptibility to neurodegeneration. This is exemplified in Parkinson’s disease with the preferential loss of dopaminergic neurons of the substantia nigra pars compacta. Using a Parkinson’s transgenic model, we conducted a single-cell spatial transcriptomic and dopaminer...

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Literature Corpus work: ed58dff2-1f61-5a45-b7a3-1629ab73bea6
DOI: 10.1101/2023.04.20.537553

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