Article
Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases.
PLoS genetics - 1 Mar 2017
Kline Rachel A, Kaifer Kevin A, Osman Erkan Y, Carella Francesco, Tiberi Ariana, Ross Jolill, Pennetta Giuseppa, Lorson Christian L, Murray Lyndsay M
Abstract excerpt
The term "motor neuron disease" encompasses a spectrum of disorders in which motor neurons are the primary pathological target. However, in both patients and animal models of these diseases, not all motor neurons are equally vulnerable, in that while some motor neurons are lost very early in disease, others remain comparatively intact, even at late stages. This creates a valuable system to investigate the factors...
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