Article

Neuronal identity defines α-synuclein and tau toxicity

2022-06-25

Abstract excerpt

Pathogenic α-synuclein and tau are critical drivers of neurodegeneration and their mutations cause neuronal loss in patients. Whether the underlying preferential neuronal vulnerability is a cell-type intrinsic property or a consequence of increased expression levels is an open question. Here, we explore cell-type specific α-synuclein and tau expression in human brain datasets and use deep phenotyping as well as br...

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Literature Corpus work: 72dde79c-5b60-5349-a064-ed96144dfa4d
DOI: 10.1101/2022.06.24.496376

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