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A topographical atlas of α-synuclein cell type-specific expression in adult mouse brain and peripheral organs

2023-11-02

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and presents pathologically with Lewy pathology and dopaminergic neuron loss. Lewy pathology contains aggregated ⍺Synuclein (⍺Syn), a protein encoded by the SNCA gene which is also mutated or duplicated in a subset of familial PD cases. Due to its predominant presynaptic localization, immunostaining f...

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Literature Corpus work
da0b5e84-6c46-5e35-a46b-11af36faece8
DOI
10.21203/rs.3.rs-3470830/v1
Open publication

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