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A topographical atlas of α-synuclein dosage and cell type-specific expression in adult mouse brain and peripheral organs

19 Mar 2024

Abstract excerpt

Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and presents pathologically with Lewy pathology and dopaminergic neurodegeneration. Lewy pathology contains aggregated α-synuclein (αSyn), a protein encoded by the SNCA gene which is also mutated or duplicated in a subset of familial PD cases. Due to its predominant presynaptic localization, immunostaining for the...

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PMID: 38504090
DOI: 10.1038/s41531-024-00672-8

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