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Spatiotemporal transcriptomics reveals distinct responses of ALDH1A1-positive and ALDH1A1-negative midbrain dopaminergic neurons to alpha-synuclein overexpression

2026-07-21

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease is characterized by the progressive and preferential degeneration of dopaminergic neurons in the substantia nigra pars compacta , and intraneuronal alpha-synuclein (αSyn) accumulation. Dopaminergic neurons (DANs) are anatomically and molecularly heterogeneous, but the impact of αSyn pathology on distinct subpopulations is not well defined. One midbrain DAN sub-population exp...

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Literature Corpus work
4c5b676c-1567-5353-8368-f601b7f799da
DOI
10.64898/2026.07.17.739121
Open publication

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Spatiotemporal transcriptomics reveals distinct responses of ALDH1A1-positive and ALDH1A1-negative midbrain dopaminergic neurons to alpha-synuclein overexpressionDOI 10.64898/2026.07.17.739121
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