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Single-nucleus transcriptomics reveals disease- and pathology-specific signatures in α-synucleinopathies

14 Nov 2024

Abstract excerpt

α-Synucleinopathies are progressive neurodegenerative disorders characterized by intracellular aggregation of α-synuclein, but their molecular pathogenesis remains unknown. Here, we explore cell-specific changes in gene expression across different α-synucleinopathies. We perform single-nucleus RNA sequencing on nearly 300 000 nuclei from the prefrontal cortex of individuals with idiopathic Parkinson's disease...

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PMID: 39546628
DOI: 10.1093/brain/awae355

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