Article

Neuronal Transcriptome Disruption, Tau Accumulation and Synapse Loss in Alzheimer’s Knock-in Mice Require Cellular Prion Protein

2023-02-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Cellular prion protein (PrP C ) is a high-affinity cell-surface receptor for Amyloid-β oligomers (Aßo). In certain overexpression models of Alzheimer’s Disease (AD), pharmacology and genetics demonstrate its essential role for synaptic plasticity impairment, memory deficits and synapse loss. However, PrP C ’s role in AD-related phenotypes with endogenous expression levels,...

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Literature Corpus work: 5e6e0603-a38d-507b-80f2-5c21579bca1f
DOI: 10.1101/2023.02.15.528700

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