Article

Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor dysfunction and cortical atrophy, independent of protein aggregation

2021-10-14

Abstract excerpt

<h4>Background</h4> A growing body of evidence suggests that nuclear alpha-synuclein (αSyn) plays a role in the pathogenesis of Parkinson’s disease (PD). However, this question has been difficult to address as controlling the localization of αSyn in experimental systems often requires protein overexpression, which affects its aggregation propensity. <h4>Methods</h4> We engineered Snca NLS mice which localize en...

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Literature Corpus work: a91cccc4-367f-5b5e-9167-c83c7afdc5cb
DOI: 10.1101/2021.10.13.464123

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