Article

Combined promoter-capture Hi-C and Hi-C analysis reveals a fine-tuned regulation of 3D chromatin architecture in colorectal cancer

2022-11-09

Abstract excerpt

<h4>ABSTRACT</h4> Hi-C is a widely used method for profiling chromosomal interactions in the 3-dimensional context. Due to limitations on the depth of sequencing, the resolution of most Hi-C datasets is often insufficient for scoring fine-scale interactions. We therefore used promoter-capture Hi-C (PCHi-C) data for mapping these subtle interactions. From multiple colorectal cancer (CRC) studies, we combined PCHi-...

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Literature Corpus work: 9a67b076-e3cb-59d5-9a4c-4141edd01196
DOI: 10.1101/2022.11.08.515643

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