Article
A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 May 2025
Tang Li, Hill Matthew C, He Mingxing, Chen Junhao, Wang Zirui, Ellinor Patrick T, Li Min
Abstract excerpt
The hierarchical organization of the eukaryotic genome is crucial for nuclear activities and cellular development. Genetic aberrations can disrupt this 3D genomic architecture, potentially driving oncogenesis. However, current research often lacks a comprehensive perspective, focusing on specific mutation types and singular 3D structural levels. Here, pathological changes from chromosomes to nucleotides are...
Read the complete abstract on PubMedTopics
- Humans
- Neoplasms
- Polymorphism, Single Nucleotide
- Genetic Variation
- Genome, Human