Article

Topologically associating domain (TAD) boundaries stable across diverse cell types are evolutionarily constrained and enriched for heritability

2020-01-11

Abstract excerpt

<h4>ABSTRACT</h4> Topologically associating domains (TADs) are fundamental units of three-dimensional (3D) nuclear organization. The regions bordering TADs—TAD boundaries—contribute to the regulation of gene expression by restricting interactions of cis-regulatory sequences to their target genes. TAD and TAD boundary disruption have been implicated in rare disease pathogenesis; however, we have a limited framewor...

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Literature Corpus work: 3c0a2813-06c0-5f2d-b5a6-c6bfa0842167
DOI: 10.1101/2020.01.10.901967

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