Article

Spatial Genome Organization as a Framework for Somatic Alterations in Human Cancer

2017-08-22

Abstract excerpt

Genomic material within the nucleus is folded into successive layers in order to package and organize the long string of linear DNA. This hierarchical level of folding is closely associated with transcriptional regulation and DNA replication. Microscopic studies concluded that genome organization inside the nucleus is not random and chromosomes within the nucleus create territories 1 . More recent chromosome conf...

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Literature Corpus work: c32b838d-e6a0-5695-b528-ce2667d8124e
DOI: 10.1101/179176

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