Article

Exploring the Effects of Genetic Variation on Gene Regulation in Cancer in the Context of 3D Genome Structure

2021-05-19

Abstract excerpt

<h4>Background: </h4> Numerous genome-wide association studies (GWAS) conducted to date revealed genetic variants associated with various diseases, including breast and prostate cancers. Despite the availability of these large-scale data, relatively few variants have been functionally characterized, mainly because the majority of single-nucleotide polymorphisms (SNPs) map to the non-coding regions of the human gen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 19fcaa86-38d5-5d82-83e3-1f7eaa2cd84f
DOI: 10.21203/rs.3.rs-496328/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring the Effects of Genetic Variation on Gene Regulation in Cancer in the Context of 3D Genome StructureDOI 10.21203/rs.3.rs-496328/v1Read

Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structure.Semantic proximity Read

Exploring the effects of genetic variation on gene regulation in cancer in the context of 3D genome structureSemantic proximity Read

Contribution of 3D genome topological domains to genetic risk of cancersSemantic proximity Read

A comprehensive catalog of 3D genome organization in diverse human genomes facilitates understanding of the impact of structural variation on chromatin structureSemantic proximity Read

Leveraging three-dimensional chromatin architecture for effective reconstruction of enhancer-target gene regulatory networkSemantic proximity Read

Discover novel disease-associated genes based on regulatory networks of long-range chromatin interactions.Semantic proximity Read

Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome.Semantic proximity Read

3DSNP: a database for linking human noncoding SNPs to their three-dimensional interacting genes.Semantic proximity Read

Contribution of 3D genome topological domains to genetic risk of cancers: a genome-wide computational studySemantic proximity Read

Maps of context-dependent putative regulatory regions and genomic signal interactions.Semantic proximity Read

Intra- and inter-chromosomal chromatin interactions mediate genetic effects on regulatory networksSemantic proximity Read

Integrative analyses of multi-tissue Hi-C and eQTL data demonstrate close spatial proximity between eQTLs and their target genesSemantic proximity Read