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Studying 3D genome evolution using genomic sequence

2019-05-23

Abstract excerpt

The 3D genome is essential to numerous key processes such as the regulation of gene expression and the replication-timing program. In vertebrates, chromatin looping is often mediated by CTCF, and marked by CTCF motif pairs in convergent orientation. Comparative Hi-C recently revealed that chromatin looping evolves across species. However, Hi-C experiments are complex and costly, which currently limits their use fo...

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Literature Corpus work
8a5f18e3-b373-592e-8807-c2bb52ed58db
DOI
10.1101/646851
Open publication

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Studying 3D genome evolution using genomic sequenceDOI 10.1101/646851
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