Article

PEhub resolves the hierarchical regulatory architecture of multi-way enhancer hubs in the human brain

2026-02-10

Abstract excerpt

Chromatin interaction assays capture regulatory architecture as stochastic pairwise contacts, limiting the ability to resolve how multiple enhancers cooperatively regulate transcription. Here we introduce a promoter-centric quantitative framework, termed PEhub, that resolves multi-way enhancer hubs as higher-order regulatory units from chromatin interaction data. By reparameterizing stochastic pairwise ligation ev...

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Literature Corpus work: 5a0eccad-c7b9-56a3-8ad2-b78b517a6be1
DOI: 10.64898/2026.02.09.704931

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