Article

Shared and distinct molecular effects of regulatory genetic variants provide insight into mechanisms of distal enhancer-promoter communication

2023-08-07

Abstract excerpt

Gene enhancers often form long-range contacts with promoters, but it remains unclear if enhancer activity and their chromosomal contacts are mediated by the same DNA sequences and recruited factors. We studied the effects of expression quantitative trait loci (eQTLs) on enhancer activity and promoter contacts in primary monocytes isolated from 34 individuals. Using eQTL-Capture Hi-C and a Bayesian approach conside...

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Literature Corpus work: 406eb3e3-e048-5ee6-9252-ff67c01dfd4e
DOI: 10.1101/2023.08.04.551251

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