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Article

Sliding Hydrogels Reveal the Modulation of Mechanosensing Attenuates the Inflammatory Phenotype of Osteoarthritic Chondrocytes in 3D.

Journal of biomedical materials research. Part A - 1 Jan 2025

Ayushman Manish, Lee Hung-Pang, Agarwal Pranay, Mikos Georgios, Tong Xinming, Jones Sarah, Sinha Sauradeep, Goodman Stuart, Bhutani Nidhi, Yang Fan

Abstract excerpt

Osteoarthritis (OA) is a prevalen degenerative joint disease with no FDA-approved therapies that can halt or reverse its progression. Current treatments address symptoms like pain and inflammation, but not underlying disease mechanisms. OA progression is marked by increased inflammation and extracellular matrix (ECM) degradation of the joint cartilage. While the role of biochemical cues has been widely studied...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39718447
DOI: 10.1002/jbm.a.37861
PMCID: PMC12790461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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