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Article

The Stiffness‐Sensitive Transcriptome of Human Tendon Stromal Cells

12 Dec 2022

Abstract excerpt

Extracellular matrix stiffness is a major regulator of cellular states. Stiffness-sensing investigations are typically performed using cells that have acquired "mechanical memory" through prolonged conditioning in rigid environments, e.g., tissue culture plastic (TCP). This potentially masks the full extent of the matrix stiffness-driven mechanosensing programs. Here, a biomaterial composed of 2D mechanovariant...

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PMID: 36509005
DOI: 10.1002/adhm.202101216

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