Article

Mechanoepigenetic Targeting of Histone Methyltransferase EZH2 Increases Potential of Scalable Manufacturing in Human Derived Primary Mesenchymal Stromal Cells

2025-12-12

Abstract excerpt

<h4>ABSTRACT</h4> Manufacturing clinical grade mesenchymal stromal cells (MSCs) remains a major bottleneck for cell-based therapies, as extensive in-vitro expansion on standard tissue-culture plastic (TCP) drives loss of stemness, reduced immunomodulatory activity, and diminished therapeutic efficacy. Although substrate stiffness is known to influence MSC fate through mechanotransduction, the epigenetic mechanism...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 971ac6c7-3e12-584d-856a-a008a552a5a8
DOI: 10.64898/2025.12.10.693526

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanoepigenetic Targeting of Histone Methyltransferase EZH2 Increases Potential of Scalable Manufacturing in Human Derived Primary Mesenchymal Stromal CellsDOI 10.64898/2025.12.10.693526Read

Mechanical memory stored through epigenetic remodeling reduces cell therapeutic potential.Semantic proximity Read

Matrix stiffness and stress relaxation regulate osteogenesis through histone demethylases KDM4B and KDM6BSemantic proximity Read

The stiffness-sensitive transcriptome of human tendon stromal cellsSemantic proximity Read

The Stiffness‐Sensitive Transcriptome of Human Tendon Stromal CellsSemantic proximity Read

An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffnessSemantic proximity Read

A Modular Bioinstructive Platform for Additive-Free, Topography-Driven Stem Cell Differentiation and PatterningSemantic proximity Read

Nuclear confinement from matrix stiffness drives epigenomic reprogramming of gingival fibroblastsSemantic proximity Read

Spatial transcriptomics defines the mechanisms of hiPSC-derived stem cell-mediated repair in human articular cartilageSemantic proximity Read

Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell linesSemantic proximity Read

Extended Exposure to Stiff Microenvironments Leads to Persistent Chromatin Remodeling in Human Mesenchymal Stem CellsSemantic proximity Read

Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffnessSemantic proximity Read

Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3Semantic proximity Read