Article

Matrix stiffness and stress relaxation regulate osteogenesis through histone demethylases KDM4B and KDM6B

2025-07-18

Abstract excerpt

Stem cells sense biophysical cues within their extracellular microenvironment and respond via mechanotransduction signaling pathways that induce changes in gene expression and associated cell fate outcomes. Histone modifying enzymes are known to drive stem cell differentiation through changes in chromatin accessibility, but little is understood as to how extracellular matrix (ECM) mechanics regulate epigenomic rem...

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Literature Corpus work: 2a63d2f4-17eb-5624-b024-691a7f56559a
DOI: 10.1101/2025.07.16.665229

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