Article

X-chromosome inactivation in human iPSCs provides insight into escape-regulated gene expression

2023-10-29

Abstract excerpt

Epigenetic variation in the X chromosome inactivation (XCI) of human induced pluripotent stem cells (hiPSCs) can impact their ability to accurately model biological sex biases. However, the gene-wise landscape of escape from XCI remains unresolved in female hiPSCs. To characterize the patterns of escape from inactivation, we performed a systematic survey of allele specific expression (ASE) in 165 female hiPSC line...

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Literature Corpus work: 5ccbf34f-b2aa-5f1f-9d8d-a684498c5ba5
DOI: 10.1101/2023.10.25.563960

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