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Article

X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations.

Proceedings of the National Academy of Sciences of the United States of America - 25 Mar 2008

Shen Yin, Matsuno Youko, Fouse Shaun D, Rao Nagesh, Root Sierra, Xu Renhe, Pellegrini Matteo, Riggs Arthur D, Fan Guoping

Abstract excerpt

X chromosome inactivation (XCI) is an essential mechanism for dosage compensation of X-linked genes in female cells. We report that subcultures from lines of female human embryonic stem cells (hESCs) exhibit variation (0-100%) for XCI markers, including XIST RNA expression and enrichment of histone H3 lysine 27 trimethylation (H3K27me3) on the inactive X chromosome (Xi). Surprisingly, regardless of the presence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18339804
DOI: 10.1073/pnas.0712018105
PMCID: PMC2290804

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