Article

Female iPSC X-chromosome inactivation (XCI) erosion and its transcriptomic effects during CRISPR gene editing and neural differentiation

2026-03-01

Abstract excerpt

<h4>SUMMARY</h4> Human induced pluripotent stem cells (hiPSC) and iPSC-differentiated neural cells, in combination with CRISPR editing, are commonly used for studying neurodevelopmental and other brain disorders. Female iPSCs undergo random X-chromosome inactivation (XCI) via epigenetic silencing by noncoding X inactive specific transcript ( XIST ). It is known that female iPSCs may lose XIST expression, leadi...

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Literature Corpus work: 247d055b-50c6-57ec-b731-a1864c3dbef4
DOI: 10.64898/2026.02.27.708613

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