Article
Dynamic allele usage of X-linked genes ameliorates neurodevelopmental disease phenotypes in brain organoids.
Nature communications - 14 Jan 2026
Bertin M, Todorov H, Frank S, Käseberg S, Menon R, Gabassi E, Foerster C, Bobon N, Furlanetto F, Soliman A, Ibrahim H M B, Engelhardt V, Birschmann L, Brennenstuhl H, Lohrer B, Mas-Sanchez A, Cesare E, Winter J, Krummeich J, Winkler J, Winner B, Weis E, Diederich S, Luck K, Lunt P, Gerber S, Baumann P, Elvassore N, Berninger B, Basilicata M F, Schweiger S, Falk S, Karow M
Abstract excerpt
While random X-chromosome inactivation in female cells of placental mammals silences one allele of the majority of X-chromosomal genes, a considerable fraction is only incompletely and variably inactivated. Human model systems to study the dynamics of incomplete X-inactivation are limited mostly to postmortem tissue, thereby disregarding developmental trajectories. Here, we used clonal human female induced...
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