Article

<i>Pgbd5</i> impacts neuronal differentiation and double strand breaks signaling in the developing cortex

2023-05-09

Abstract excerpt

<h4>SUMMARY</h4> Transposable Element Derived 5 ( Pgbd5 ) is an evolutionary conserved gene encoding an endonuclease predominantly expressed in the nervous system and known to drive oncogenic DNA rearrangements in childhood solid tumors. However, its physiological role in brain development has remained poorly understood. Here we show that Pgbd5 is required for proper neuronal differentiation and radial migratio...

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Literature Corpus work: 584e00f4-e386-5a9d-b2d5-b4ff0ad7eff2
DOI: 10.1101/2023.05.09.539730

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