Article

A transposase-derived gene required for human brain development

2023-04-28

Abstract excerpt

DNA transposable elements and transposase-derived genes are present in most living organisms, including vertebrates, but their function is largely unknown. PiggyBac Transposable Element Derived 5 (PGBD5) is an evolutionarily conserved vertebrate DNA transposase-derived gene with retained nuclease activity in human cells. Vertebrate brain development is known to be associated with prominent neuronal cell death and...

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Literature Corpus work: f9e89460-7fff-54f0-85ef-9aa022ac935b
DOI: 10.1101/2023.04.28.538770

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