Article

CHD8 Regulates Cellular Homeostasis and Neuronal Function Genes Across Multiple Models of <i>CHD8</i> Haploinsufficiency

2018-07-23

Abstract excerpt

<h4>ABSTRACT</h4> The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Recent sequencing of patient mutations has linked de novo loss-of-function mutations to chromatin remodeling factors with specific, causal roles in neurodevelopmental disorders. Characterizing cellular and molecular phenotypes arising from haploinsufficiency of chr...

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Literature Corpus work: 6adf43d7-3f79-5e46-9215-2f8f033fb331
DOI: 10.1101/375238

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