Article

Childhood cancer mutagenesis caused by a domesticated DNA transposase

2022-07-05

Abstract excerpt

Genomic rearrangements are a hallmark of most solid tumors, including medulloblastoma, one of the most common brain tumors in children. Childhood cancers involve dysregulated cell development, but their mutational causes remain largely unknown. One of the most common forms of medulloblastoma is caused by ectopic activation of Sonic Hedgehog (SHH) signaling in cerebellar granule cell progenitors, associated with ge...

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Literature Corpus work: 1f713f76-a07d-5d73-aafb-756280a2333f
DOI: 10.1101/2022.07.05.498128

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