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Disruption of <i>Histone H4C</i> genes impairs skeletal development and cortical neurogenesis, modeling rare neurodevelopmental syndromes

2026-07-14

Abstract excerpt

Histone proteins, which reside in the nuclei of eukaryotic cells, are involved in diverse cellular processes. The core histone H4 serves as a structural component of the nucleosome. Patients carrying mutations in H4Clustered histone ( H4C ) genes exhibit a broad spectrum of developmental abnormalities, including short stature, microcephaly, intellectual disability, growth retardation, and digital anomalies. Howev...

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Literature Corpus work
c40bc544-3a3f-548a-8036-529d8e6e389c
DOI
10.64898/2026.07.12.738071
Open publication

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Disruption of <i>Histone H4C</i> genes impairs skeletal development and cortical neurogenesis, modeling rare neurodevelopmental syndromesDOI 10.64898/2026.07.12.738071
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