Article

Cell type-specific enrichment of somatic aneuploidy in the mammalian brain

2023-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Somatic mutations alter the genomes of a subset of an individual’s brain cells 1–3 , impacting gene regulation and contributing to disease processes 4,5 . Mosaic single nucleotide variants have been characterized with single-cell resolution in the brain 2,3 , but we have limited information about large-scale structural variation, including whole-chromosome duplication or loss 1,6,7 . We used...

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Literature Corpus work: 8eab0391-115b-539c-8703-f889449bc2b0
DOI: 10.1101/2023.12.18.572285

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