Article

Epigenomic landscape of the developing human rhombic lip reveals gene regulatory network and non-coding loci of developmental, evolutionary, and disease relevance

2025-10-31

Abstract excerpt

The cerebellar rhombic lip neural progenitor niche of the prenatal hindbrain is an anatomical structure critical for cerebellar glutamatergic neurogenesis. Humans have elaborated the rhombic lip niche to include a rhombic lip subventricular zone (RL-SVZ) not seen in mice or macaques. Although developmental disruptions of this progenitor zone can cause cerebellar growth abnormalities – from malformations to tumors...

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Literature Corpus work: b6bc0d9c-ffb4-5f98-a0f9-94c9b390053b
DOI: 10.1101/2025.10.30.685586

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