Article

Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors

2017-02-23

Abstract excerpt

Genomic rearrangements are a hallmark of childhood solid tumors, but their mutational causes remain poorly understood. Here, we identify the piggyBac transposable element derived 5 ( PGBD5 ) gene as an enzymatically active human DNA transposase expressed in the majority of rhabdoid tumors, a lethal childhood cancer. Using assembly-based whole-genome DNA sequencing, we observed previously unknown somatic genomic...

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Literature Corpus work: 0a436564-51e9-505a-8ffe-66a2aef30655
DOI: 10.1101/111138

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