Article

Cell type-specific dysregulation of gene expression due to <i>Chd8</i> haploinsufficiency during mouse cortical development

2024-08-15

Abstract excerpt

<h4>Summary</h4> Disruptive variants in the chromodomain helicase CHD8 , which acts as a transcriptional regulator during neurodevelopment, are strongly associated with risk for autism spectrum disorder (ASD). Loss of CHD8 function is hypothesized to perturb gene regulatory networks in the developing brain, thereby contributing to ASD etiology. However, insight into the cell type-specific transcriptional effects...

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Literature Corpus work: 3fb000fc-8f1c-5d48-bcb7-fe08a946ee8e
DOI: 10.1101/2024.08.14.608000

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