Article
Cell-type-specific 3D epigenomes in the developing human cortex.
Nature - 1 Nov 2020
Song Michael, Pebworth Mark-Phillip, Yang Xiaoyu, Abnousi Armen, Fan Changxu, Wen Jia, Rosen Jonathan D, Choudhary Mayank N K, Cui Xiekui, Jones Ian R, Bergenholtz Seth, Eze Ugomma C, Juric Ivan, Li Bingkun, Maliskova Lenka, Lee Jerry, Liu Weifang, Pollen Alex A, Li Yun, Wang Ting, Hu Ming, Kriegstein Arnold R, Shen Yin
Abstract excerpt
Lineage-specific epigenomic changes during human corticogenesis have been difficult to study owing to challenges with sample availability and tissue heterogeneity. For example, previous studies using single-cell RNA sequencing identified at least 9 major cell types and up to 26 distinct subtypes in the dorsal cortex alone1,2. Here we characterize cell-type-specific cis-regulatory chromatin interactions, open...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.