Article

Epigenetic regulator KDM5B loss-of-function delays neuronal differentiation of human iPSCs

2026-04-20

Abstract excerpt

<title>Abstract</title> <p>KDM5B is a histone demethylase implicated in early development, with loss-of-function mutations linked to recessive neurodevelopmental disorders exhibiting variable penetrance. Despite this, its molecular function during early human neurogenesis remains unclear. To address this, we investigated the function of KDM5B in early neuronal differentiation by CRISPR knock-out of KDM5B in human...

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Literature Corpus work: 40276824-30fc-5ad7-ba2b-3e0f0920f0ca
DOI: 10.21203/rs.3.rs-8989803/v1

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