Article

<i>CHD8</i> regulates the balance between proliferation and differentiation of human iPSCs in neural development

2019-08-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Chromodomain helicase DNA-binding protein 8 (CHD8) , which encodes a chromatin remodeling protein that regulates Wnt/β-catenin mediated gene expression, is one of the most strongly associated genes with autism spectrum disorder (ASD). Characterization of ASD patients with CHD8 disrupting mutations and animal and stem cell models of CHD8 deficiency suggest that CHD8 plays a r...

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Literature Corpus work: 136cba18-2b77-54e2-be20-6ca81da11aa5
DOI: 10.1101/732693

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