Article

POGZ safeguards neuronal gene chromatin architecture and transcription

2026-07-03

Abstract excerpt

Disruption of chromatin organization is a common pathogenic mechanism in neurodevelopmental disorders, yet how changes in 3D genome architecture relate to transcriptional dysfunction in the developing brain remains unclear. POGZ, a transposase-derived chromatin regulator mutated in White–Sutton syndrome and autism spectrum disorder (ASD) has been linked to both heterochromatin and accessible regulatory DNA, but it...

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Literature Corpus work: 2ef43dfe-255d-552f-8b4c-e3e8ededfd7e
DOI: 10.64898/2026.07.02.736104

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