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Article

Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs.

Genome research - 1 Apr 2012

Sharifpoor Sara, van Dyk Dewald, Costanzo Michael, Baryshnikova Anastasia, Friesen Helena, Douglas Alison C, Youn Ji-Young, VanderSluis Benjamin, Myers Chad L, Papp Balázs, Boone Charles, Andrews Brenda J

Abstract excerpt

A combinatorial genetic perturbation strategy was applied to interrogate the yeast kinome on a genome-wide scale. We assessed the global effects of gene overexpression or gene deletion to map an integrated genetic interaction network of synthetic dosage lethal (SDL) and loss-of-function genetic interactions (GIs) for 92 kinases, producing a meta-network of 8700 GIs enriched for pathways known to be regulated by...

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PMID: 22282571
DOI: 10.1101/gr.129213.111
PMCID: PMC3317160

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Source receipt: pubmed, retrieved 7 Sept 2026.

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