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Article

A global genetic interaction map of a human cell reveals conserved principles of genetic networks

2025-07-02

Abstract excerpt

We generated a genome-scale, genetic interaction network from the analysis of more than 4 million double mutants in the haploid human cell line, HAP1. The network maps ∼90,000 genetic interactions, including thousands of extreme synthetic lethal and genetic suppression interactions. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to protein co...

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Identifiers and source

Literature Corpus work
b4c9eaf0-0d2a-5891-a915-6176b76f0c04
DOI
10.1101/2025.06.30.662193
Open publication

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A global genetic interaction map of a human cell reveals conserved principles of genetic networksDOI 10.1101/2025.06.30.662193
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